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Year : 2015  |  Volume : 5  |  Issue : 2  |  Page : 114-115

Prior cholecystectomy predisposes to acute pancreatitis in codeine-prescribed patients

1 Department of Cardiology, Sanko University School of Medicine, Gaziantep, Turkey
2 Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey
3 Department of Internal Medicine, Necip Fazil Metropolitan Hospital, Kahramanmaras, Turkey
4 Department of Internal Medicine, Harran University School of Medicine, Sanliurfa, Turkey

Correspondence Address:
Hakan Buyukhatipoglu
Gaziantep University, School of Medicine Department of Internal Medicine, Division of Medical Oncology, Kilis Yolu Uzeri - 27310, Gaziantep
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5151.158416

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In this paper, we report a case of drug-induced pancreatitis just after taking a pain pill including a low-dose combination of acetaminophen and codeine. Codeine-induced pancreatitis has been rarely reported, however, well-established. The proposed mechanism for codeine-induced pancreatitis is by increasing Oddi sphincter pressure. However, the clinically important point is that the codeine-induced pancreatitis is seen almost only in the cholecystectomized patients due to lacking of its reservoir capacity. Codeine is commonly used alone or in combination in pain medicine. Therefore, it is fairly important to question whether a patient underwent cholecystectomy when a physician decides to prescribe codeine-included preparations.

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