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EXPERT COMMENTARY
Year : 2018  |  Volume : 8  |  Issue : 2  |  Page : 57-62

Evidence-based approach to the trauma patient in extremis: Transitioning from exclusive emergency department thoracotomy use to protocolized approaches incorporating resuscitative endovascular balloon occlusion of the aorta


1 OhioHealth Grant Medical Center, Grant Level I Trauma Center, Columbus, Ohio, USA
2 Level I Regional Trauma Center and Network, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA

Date of Web Publication18-Jun-2018

Correspondence Address:
Dr. Stanislaw P Stawicki
Level I Regional Trauma Center and Network, St. Luke's University Health Network, 801 Ostrum Street, Bethlehem, Pennsylvania
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJCIIS.IJCIIS_28_18

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How to cite this article:
Spalding M C, Thomas PG, O'Mara M S, Ramirez CL, Yanagawa FS, Hon HH, Hoey BA, Hoff WS, Cipolla J, Stawicki SP. Evidence-based approach to the trauma patient in extremis: Transitioning from exclusive emergency department thoracotomy use to protocolized approaches incorporating resuscitative endovascular balloon occlusion of the aorta. Int J Crit Illn Inj Sci 2018;8:57-62

How to cite this URL:
Spalding M C, Thomas PG, O'Mara M S, Ramirez CL, Yanagawa FS, Hon HH, Hoey BA, Hoff WS, Cipolla J, Stawicki SP. Evidence-based approach to the trauma patient in extremis: Transitioning from exclusive emergency department thoracotomy use to protocolized approaches incorporating resuscitative endovascular balloon occlusion of the aorta. Int J Crit Illn Inj Sci [serial online] 2018 [cited 2018 Sep 20];8:57-62. Available from: http://www.ijciis.org/text.asp?2018/8/2/57/234576




   Introduction Top


The most severely injured patients who arrive to emergency departments (EDs) in extremis present the most difficult challenge to traumatologists. For decades, unacceptably high mortality rates in this subset of patients evaded even the most extreme and invasive life-saving intervention – the ED thoracotomy (EDT).[1],[2],[3] The physiological premise behind the EDT is to perform three essential maneuvers: to relieve cardiac tamponade, to control hemorrhage, and to achieve temporary aortic occlusion.[4] Aortic cross-clamping during EDT increases coronary blood flow, cardiac output, mean arterial pressure, carotid blood flow, and brain perfusion/oxygenation.[5] The success of this procedure is varied depending on the cause of traumatic cardiac arrest, but a review of 868 patients from a single center showed an approximate 5% survival rate.[6] According to literature compilation by Pust and Namias, average survival for blunt traumatic EDT was 1.6%, with corresponding figure being approximately 10 times higher (16.8%) for penetrating traumatic EDT.[7] It has been postulated that significant contribution to morbidity and mortality within the EDT population may be associated with the thoracotomy itself,[8] suggesting that the performance of EDT should be restricted to a subset of patients who – based on best available scientific evidence – have the most reasonable chance of survival. By any measure, the performance of EDT simply to ensure “procedural skills maintenance” is ethically questionable, and there are increasing doubts about the benefit of entering an uninjured body cavity to address an injury elsewhere.

Balloon occlusion of the aorta is an alternative to open aortic cross-clamping and dates back to the treatment of traumatic war injuries as early as the 1950s. It is now widely accepted it was Hughes who reported the initial experience with the primitive precursor of the “Resuscitative Endovascular Balloon Occlusion of the Aorta” (REBOA) during the Korean War.[9] Several decades passed until the technique was proposed as an alternative to EDT and open aortic cross-clamping in penetrating abdominal trauma.[10] However, this early experience with REBOA highlighted complications of paraplegia, thrombosis, and balloon misadventures that limited wide adoption. In contrast, more recent studies have highlighted the hemodynamic benefits of REBOA,[11] relatively low complication rates,[12] and broadening clinical indications.[13],[14],[15] Gradually, studies comparing outcomes of REBOA versus EDT have been published.[14],[16],[17] This commentary attempts to compile the best available evidence on this topic and present to the reader an argument that, given the more recent literature experiences and reports, reconsideration of REBOA and its reclassification from “adjunctive” to “primary” modality is warranted for patients with extra thoracic injuries who present in extremis.


   Neurologically Versus Nonneurologically Intact Survival Top


One major challenge faced by intensivists who provide care for patients who survive extreme traumatic injuries is the differentiation between individuals with meaningful functional survival and those who survive but are not neurologically intact.[18] The finding of neurologically intact survival varies greatly across the literature and tends to be correlated to the mechanism of injury, the presence of signs of life (SOL), and time from injury to ED arrival.[4] The Eastern Association for the Surgery of Trauma guidelines on evidence-based approach to EDT patient selection cite poor overall survival figures, both for neurologically intact and nonneurologically intact patients, especially in the setting of blunt trauma [Table 1].[18]
Table 1: Descriptive survival rates for EDT, derived from Seamon, et al. J Trauma Acute Care Surg 2015;79(1):159-173. Although evidence for any of the interventions and scenarios listed is of poor quality, important survival-related trends emerge, suggesting that the EDT is most indicated for patients suffering from penetrating chest or non-compressible extrathoracic trauma

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Currently accepted definitions of what constitutes SOL tend to be vague and appear open to interpretation.[18],[19],[20] The fact that providers tend do resort to EDT based on liberal interpretation of existing guidelines means that various degrees of both overtriage and undertriage exist. For many trauma surgeons, the availability of an EDT as the “best option” creates a difficult medical and ethical choice: should one routinely perform EDTs for blunt trauma victims with <5% chance of survival and 2.5% neurologically intact survival [Table 1]?[18] Is the average number of 22 EDTs to save 1 life justifiable? What about the 42 EDTs to allow 1 patient to have a neurologically intact recovery? For some trauma surgeons, a procedure that may potentially save a life is justifiable no matter what the cost or consequences. For others, the overwhelming emotional burden of operating on a patient with such high degree of futility may add to the fairly recently described posttraumatic stress disorder among trauma practitioners.[21] Of importance, the risk of accidental health worker exposure to blood or bodily fluids during EDTs is substantial. Elevated prevalence of HIV and hepatitis C in some trauma populations, combined with a provider injury rate as high as 10% may create a potentially dangerous environment for the trauma team.[22],[23] The risk-benefit ratio must be carefully weighed before triggering the decision to proceed. For many traumatologists, the driving force for performing EDTs in the setting of overwhelming futility may also be due to the additional concern of being judged by their peers for “not having done enough.” Some within the latter group revert to purely protocolized responses and simply “follow guidelines” and “implement recommendations,” which again may be prone to inconsistencies and are subject to a broad range of interpretations.

The advent of REBOA has created another pathway to aortic occlusion for those who consider EDT to be overly aggressive and unjustifiably invasive. Moreover, with the overall reported survival of all REBOA patients rivaling or exceeding survival rates of the “most favorable” EDT outcome group (e.g., victims of penetrating thoracic injuries with SOL present on arrival), indications for EDT are bound to become inherently constrained in the era of wider availability of the less invasive option [Figure 1] and [Table 1].[14],[15],[16],[17],[18]
Figure 1: Pooled analysis of data from five published studies, combined with OhioHealth Grant Medical Center and St. Luke's University Health Network aggregate experience, comparing emergency department thoracotomy to resuscitative endovascular balloon occlusion of the aorta suggests potential survival advantage of resuscitative endovascular balloon occlusion of the aorta over emergency department thoracotomy. Further data are required to better define the magnitude of any potential benefit of resuscitative endovascular balloon occlusion of the aorta, focusing on patients with extrathoracic injuries who arrive to emergency departments in extremis. Deidentified, aggregate, IRB-exempt outcome data from OhioHealth Grant Level I Trauma Center and St. Luke's University Health Network Level I Trauma Center

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   Resuscitative Endovascular Balloon Occlusion of the Aorta: Indications Top


Currently accepted indications for REBOA are the same as for EDT, with the exception of suspected intrathoracic injury. This specifically includes those patients presenting with cardiac arrest of <10 min secondary to exsanguination, or patients in hemorrhagic shock from suspected intra-abdominal or pelvic hemorrhage who are partial or nonresponders to resuscitation. Placement of REBOA is contraindicated in the setting of suspected intrathoracic injury, specifically in patients with clinical/anatomic evidence of proximal traumatic aortic injury. Placement of a REBOA in these circumstances increases the risk of exacerbating such proximal injuries.[24]

Insertion of the REBOA catheter requires common femoral artery (CFA) access, either percutaneously or through a cut-down approach. More recently introduced REBOA devices provide greater flexibility than earlier models in that they are amenable to insertion through a 7- or 8-French sheath in the CFA, without the need for fluoroscopy or specialized guide wires. Aortic occlusion is accomplished by filling the balloon on the device at one of two locations, Zone 1 or Zone 3, depending on the suspected source of hemorrhage [Figure 2]. Zone 1 includes the vessels beginning from the origin of the left subclavian artery to the celiac artery. The balloon is inflated at the distal portion of Zone 1 for suspected intra-abdominal hemorrhage. Zone 3 includes the aorta from below the renal artery to the aortic bifurcation; the balloon is inflated here in the setting of suspected pelvic hemorrhage. Zone 2 includes the aorta from the celiac artery to renal arteries and is avoided during balloon occlusion to prevent injury to the associated critical vessels and organs.[25]
Figure 2: Schematic drawing outlining the three “landing zones” (green) for the intra-aortic placement of the resuscitative endovascular balloon occlusion of the aorta device. Drawing courtesy of Dr. Heidi H. Hon

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   Resuscitative Endovascular Balloon Occlusion of the Aorta: Clinical Considerations Top


There are several very important considerations when using REBOA, each associated with a significant potential to affect patient outcomes. For example, time to initiation of REBOA therapy (e.g., “time to balloon inflation”) has been noted to be significantly longer in nonsurvivors (91 min) when compared to survivors (46 min) in a small study of patients with severe pelvic fractures.[26] This may be partly due to increased difficulty in obtaining CFA access in patients who are in hemorrhagic shock or pulseless. Of note, once arterial access is obtained, time to aortic occlusion is significantly less with REBOA compared to EDT.[24],[25] In the context of this particular observation, it may be that REBOA should be utilized earlier and more liberally, with the primary goal of preventing trauma-related cardiac arrest, as opposed to being a “rescue therapy” that is deployed as a “last ditch” effort. Further research will be needed to better answer this question, but experiences with other intravascular support modalities for trauma patients suggest “that the earlier the deployment, the better.”[27]

Results using hybrid approach combining REBOA and EDT have been described, but reported data are difficult to interpret due to higher overall Injury Severity Score and Abbreviated Injury scale - chest scores among patients undergoing simultaneous EDT and REBOA.[28] Extreme caution is required when employing endovascular and direct aortic vascular occlusion concurrently, with special attention needed to avoid mechanical complications of mistakenly cross-clamping the intra-aortic balloon, or creating iatrogenic injuries that contribute to further blood loss and propagation of the hemorrhagic shock.

Finally, it has been recently suggested that there is no significant difference between properly performed external chest compressions and open cardiac massage in terms of clinical outcomes.[29] The latter point puts into question the use of EDT as a maneuver to perform “more effective” cardiac compressions. Based on the above evidence, REBOA combined with external chest compressions may be “as good as” direct cardiac massage and would simultaneously control nonthoracic hemorrhage and achieve temporary aortic occlusion, bypassing the morbidity of an EDT. Again, expedient yet careful consideration must be made whether to proceed with EDT or REBOA, weighing pertinent risks and benefits, preferably by a provider who is experienced and comfortable with both decisional and technical aspects involved in such intervention(s).


   The Importance of Dedicated Clinical Training Top


Increasing availability and decreasing invasiveness of REBOA devices created immense need for wide-scale dissemination of didactic and technical training. The Endovascular Skills for Trauma and Resuscitative Surgery (ESTARS) course is one of the best established and most comprehensive programs within this niche.[30] Other courses such as the basic endovascular skills for trauma or similar “training packages” are available for physician and practitioner training as well. In general, REBOA education should incorporate required reading materials, familiarization with equipment, standardized procedural training, written and practical assessments, scripted scenarios, and a certificate of completion.[31],[32] More specialized courses covering REBOA deployment specifically for Zone III of the Aorta [Figure 2] in the setting of pelvic and groin hemorrhage have been developed in the United Kingdom.[32]

In terms of overall educational effectiveness, the ESTARS course in particular has shown significant improvement in both knowledge and procedural task times among acute care surgeons who completed the curriculum.[30],[31] There appears to be no correlation between REBOA proficiency and the learners' experiences in residency, frequency of line placement, or other tested parameters. These educational data are encouraging to both inexperienced trauma surgeons with limited exposure and those who only infrequently utilize endovascular techniques.


   Resuscitative Endovascular Balloon Occlusion of the Aorta: Clinical Outcomes Top


In terms of overall clinical outcomes, evidence comparing EDT and REBOA continues to be limited, with substantial biases inherent to methodological deficiencies. Reported survival rates vary significantly between studies from the US, Japan, and Europe (range, 13% to 67%), likely because of differences in methodology, inclusion criteria, and the interventions performed. However, important generalizations can be made with a reasonable margin of confidence. First, the overall survival, as reported in each individual study, is universally better for patients treated with REBOA than for those managed with EDT [Figure 1] and [Table 2]. In addition, available data regarding the proportion of survivors discharged to home appear to favor REBOA over EDT [Table 2]. At the same time, there are important considerations and biases that make direct comparison of the two management approaches less meaningful, including the potential for patient selection bias and severity of injury/illness differences. In any case, even if one assumes that the actual risk-adjusted survival for patients undergoing REBOA is as much as 30%–50% lower than currently reported, aggregate outcomes following endovascular balloon placement are still superior to those of EDT.
Table 2: Comparison of cumulative experiences with resuscitative endovascular balloon occlusion of the aorta and emergency department thoracotomy; pooled data were compiled from multiple sources (see figure legend for details)

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At the same time, it is important to note that REBOA is not without its own unique morbidity profile. Most common complications are related to vascular access and ischemia-reperfusion injury. Technical complications include femoral artery pseudoaneurysm, distal embolism, and limb ischemia.[24],[33] A comparison of complications related to REBOA versus EDT is provided in [Table 3].
Table 3: Comparison of complications of resuscitative endovascular balloon occlusion of the aorta versus emergency department thoracotomy

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There are also aortic complications related to balloon inflation and occlusion of different aortic zones [Figure 2]. Zone 1 deployment is associated with elevated risk of organ ischemia, especially with aortic occlusion times greater than 1 h. Zone 3 deployment allows for longer occlusion time compared to Zone 1 placement but provides less support for myocardial and cerebral perfusion. Balloons that are placed in improper zones may result in unwanted and increased hemorrhage proximally, as well as ischemia distally. Because balloon positioning is “blind”, overinflation or inadvertent migration of the device can result in aortic intimal injury.[24]

Furthermore, REBOA-related complications may be compounded when performed under emergency situations by providers with limited experience. As such, REBOA should only be utilized by providers who have received adequate training and understand the risks, benefits, and complications associated with both REBOA and EDT.[24]


   Conclusion Top


In the presence of increasing device availability and easily attainable training for REBOA, the current set of indications for EDT should be carefully reevaluated in the context of the overall risk-benefit equation. Patients with blunt extrathoracic traumatic injuries may represent the subset that benefits the most from REBOA placement. Although reported experiences comparing EDT with REBOA are certainly imperfect in terms of both quality and quantity, absolute differences in survival, especially for penetrating and blunt extrathoracic injuries, demonstrate similar magnitude of benefit across all published sources for patients who present in extremis. It must be emphasized that EDT remains a valuable primary therapeutic modality for patients with penetrating thoracic and extrathoracic injuries who present with SOL, as well as in carefully selected blunt trauma patients with certain readily correctable physiologic conditions (e.g., noncompressible hemorrhage, cardiac tamponade).



 
   References Top

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[PUBMED]    


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    Tables

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