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Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 75-81

Immunoregulation of bone remodelling

1 Department of Orthopaedics, Co Trauma Center I/C, C S M Medical University, Lucknow, India
2 Department of Biochemistry, C S M Medical University, Lucknow, India
3 Department of Orthopaedic, C S M Medical University, Lucknow, India
4 Department of Physiology, C S M Medical University, Lucknow, India

Correspondence Address:
Ajai Singh
2/59, Viram Khand, Gomti Nagar, Lucknow
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5151.97271

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Remodeling, a continuous physiological process maintains the strength of the bones, which maintains a delicate balance between bone formation and resorption process. This review gives an insight to the complex interaction and correlation between the bone remodeling and the corresponding changes in host immunological environment and also summarises the most recent developments occuring in the understanding of this complex field. T cells, both directly and indirectly increase the expression of receptor activator of nuclear factor kB ligand (RANKL); a vital step in the activation of osteoclasts, thus positively regulates the osteoclastogenesis. Though various cytokines, chemikines, transcription factors and co-stimulatory molecules are shared by both skeletal and immune systems, but researches are being conducted to establish and analyse their role and / or control on this complex but vital process. The understanding of this part of research may open new horizons in the management of inflammatory and autoimmune diseases, resulting into bone loss and that of osteoporosis also.

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