International Journal of Critical Illness and Injury Science

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 9  |  Issue : 2  |  Page : 69--74

Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury


Hayder M Al-Kuraishy, Ali I Al-Gareeb, Nawar R Hussien 
 Department of Pharmacology, Toxicology and Medicine, College of Medicine Al-Mustansiriya University, Baghdad, Iraq

Correspondence Address:
Prof. Hayder M Al-Kuraishy
Department of Pharmacology, Toxicology and Medicine, College of Medicine Al-Mustansiriya University, Baghdad
Iraq

Objective: To evaluate the renoprotective effects of berberine and/or pentoxifylline in reduction of diclofenac-induced acute kidney injury (AKI) in rats. Material and Methods: Fifty male Sprague-Dawley rats were allocated into five groups, Group 1: Rats treated with distilled water plus normal saline for 12 days. Group 2: Rats treated with distilled water plus diclofenac for 12 days. Group 3: Rats treated with berberine plus diclofenac for 12 days. Group 4: Rats treated with pentoxifylline plus diclofenac for 12 days. Group 5: Rats treated with berberine + pentoxifylline plus diclofenac 15 mg/kg for 12 days. Blood urea, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecules (KIM-1), and cystatin-c were used to measure the severity of AKI. Results: Diclofenac led to significant AKI by significant elevation of blood urea, serum creatinine, KIM-1, and NGAL. Treatment with berberine showed no significant effect on all biomarkers level compared to diclofenac group except on serum KIM-1 level which also seen in the pentoxifylline group whereas combination of berberine and pentoxifylline led to more significant effect in the reduction of all renal biomarkers. Conclusion: Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced AKI.


How to cite this article:
Al-Kuraishy HM, Al-Gareeb AI, Hussien NR. Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury.Int J Crit Illn Inj Sci 2019;9:69-74


How to cite this URL:
Al-Kuraishy HM, Al-Gareeb AI, Hussien NR. Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury. Int J Crit Illn Inj Sci [serial online] 2019 [cited 2021 Jan 20 ];9:69-74
Available from: https://www.ijciis.org/article.asp?issn=2229-5151;year=2019;volume=9;issue=2;spage=69;epage=74;aulast=Al-Kuraishy;type=0