International Journal of Critical Illness and Injury Science

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 11  |  Issue : 4  |  Page : 236--245

The burden and characteristics of nosocomial infections in an intensive care unit: A cross-sectional study of clinical and nonclinical samples at a tertiary hospital of Nepal


Manisha Karn1, Dipak Bhargava2, Binod Dhungel1, Megha Raj Banjara1, Komal Raj Rijal1, Prakash Ghimire1 
1 Department of Microbiology, Central Tribhuvan University, Kirtipur, Kathmandu, Nepal
2 National Medical College & Teaching Hospital, Birgunj, Nepal

Correspondence Address:
Dr. Komal Raj Rijal
Department of Microbiology, Central Tribhuvan University, Kirtipur, Kathmandu
Nepal

Background: Patients at intensive care units (ICUs) are vulnerable to acquiring nosocomial infections. The main objective of this study was to explore and characterize the burden of nosocomial infections from an ICU of National Medical College and Teaching Hospital (NMCTH), Birgunj, Nepal. Methods: A prospective hospital-based study was conducted between April and December 2018 at NMCTH, Birgunj, Province 2, of Nepal. A total of 374 specimens including clinical specimens (n = 190) from patients admitted in an ICU and animate and inanimate environmental samples (n = 184) from the ICU were collected. Collected specimens were cultured in specific microbiological media, and microbial isolates were identified and subjected to antibiotic susceptibility test. Results: Altogether, 374 specimens (190 clinical specimens and 184 nonclinical) of an ICU were analyzed. Out of 190 clinical specimens, 51% (97/190) showed bacterial growth. Isolated bacteria were Staphylococcus aureus (33%; 32/97), Escherichia coli (20.6%; 20/97), Klebsiella spp. (15.5%; 15/97), Pseudomonas spp. (11.3%; 11/97), and Acinetobacter spp. (11.3%; 11/97). Out of 184 nonclinical specimens, 51.6% (95/184) of the samples showed microbial growth. Among the isolates, Klebsiella spp. predominated (30.6%; 26/85) the growth, followed by S. aureus (22.4%; 19/85), Acinetobacter spp. (21.2%; 18/85), and Pseudomonas spp. (17.6%; 15/85). Among all clinical and nonclinical isolates, 61.9% (60/97) of the clinical specimens and 65.9% (56/85) of the nonclinical specimens showed multidrug resistance (MDR). Conclusion: Two-thirds of the specimens from both clinical and nonclinical specimens showed MDR. Urgent actions are required to address the augmented rate of nosocomial infections and MDR bacteria among ICUs in Nepal.


How to cite this article:
Karn M, Bhargava D, Dhungel B, Banjara MR, Rijal KR, Ghimire P. The burden and characteristics of nosocomial infections in an intensive care unit: A cross-sectional study of clinical and nonclinical samples at a tertiary hospital of Nepal.Int J Crit Illn Inj Sci 2021;11:236-245


How to cite this URL:
Karn M, Bhargava D, Dhungel B, Banjara MR, Rijal KR, Ghimire P. The burden and characteristics of nosocomial infections in an intensive care unit: A cross-sectional study of clinical and nonclinical samples at a tertiary hospital of Nepal. Int J Crit Illn Inj Sci [serial online] 2021 [cited 2022 Nov 29 ];11:236-245
Available from: https://www.ijciis.org/article.asp?issn=2229-5151;year=2021;volume=11;issue=4;spage=236;epage=245;aulast=Karn;type=0